I can help with this. But a lot depends on what scene you're looking for and how old you are. But I'll start near your hotel since you're staying on S. Acadian.
If you go left on Perkins from S Acadian, you have The Bulldog (pub-style, mixed crowd, good beer selection, great patio, my neighborhood watering hole

), Uncle Earl's (college crowd, dance music, etc.), and Happy Note (hole-in-wall, juke box, few TVs).
Go right on Perkins and you've got the Perkins Overpass area: Chelsea's (live music, good food, mixed crowd), Duvic's (good martinis, eclectic crowd), Ivar's (pub/restaurant, mixed crowd). All within walking distance of each other. And a few more places I know I'm forgetting.
If you want to stick around campus, you've got North Gate Tavern, The Varsity and Chimes Restaurant (LSU institution), and Serrano's. The last 2 are more restaurants than bars, but Chimes has an excellent beer selection. If you want to party like an LSU student and aren't over 25, go to Tigerland.
Downtown is good if you want variety and like Bud said, 3rd Street is the place to be with Happy's Irish Pub and Roux House (live music, good beer, mixed crowd), Boudreaux and Thibodeaux's (swamp-themed decor, mixed crowd, generally pretty fun), Punchers (MMA crowd), Red Star (fun place, eccentric crowd), and Wine Loft (if you want to class it up).
Hope this helps!
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