Easily Ryan Perrilloux is the best I've seen... I have seen him had 10 TDs in a game, 7 passing, 3 rushing. I've seen 400+ passing, and 200+ rushing in the same game
Brian, Bucky and Todd are all good picks. I played either college or HS football with all three. It is my opinion Todd was the best athlete out of the 3 with Bucky a close second and Brian 3rd. But Brian definitely had the best pro career.
Peyton graduated from Newman in 1994 and Eli graduated in 1999 (started at QB his sophomore season in 1996), so its possible he could've played against both, as a Freshman and a Senior I guess?