What kind of personal experiences? I can give you good ones and bad ones, on both LSD, and Mushrooms. Never done DMT, but wouldn't say I wouldn't try it at least once if given the opportunity. I haven't done any psychedelics in years though, and probably wouldn't ever again unless it was DMT, just to have the experience. Also done peyote too. I haven't done ayahuasca either, but Ive heard it's insane. I think alot of people should at least experience hallucinogens. As far as all the other drugs, that's another story. You have your opiates, your amphetamines, benzos, and then cocaine. I don't consider weed a drug, so I'm going to say best drug would be Opium, worst would be Heroin as far as my experiences go, and I know that may sound weird considering how closely related those 2 are but that's just my personal opinion.